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49ers at Colts: December 22, 2025

The San Francisco 49ers beat the Indianapolis Colts 48-27 at Lucas Oil Stadium on December 22, 2025 (2025 regular season).

Final · Played December 22, 2025 · Updated October 16, 2026 at 10:55 PM ET · StatsNext box-score records

Most passing yards: Brock Purdy (49ers, 295). Most rushing yards: Christian McCaffrey (49ers, 117); Jonathan Taylor (Colts, 46). Most receiving yards: George Kittle (49ers, 115); Josh Downs (Colts, 65).

Scoring by quarter

TeamQ1Q2Q3Q4Final
San Francisco 49ers1410101448
Indianapolis Colts7103727

Team comparison

Team statsSFIND
Total yards440312
Passing yards295254
Rushing yards14558
First downs2819
Yards per play6.75.4
Turnovers12
Penalty yards3645
Red zone (scores/trips)4/62/2

What stood out

  • The 49ers out-gained the Colts 440 to 312 total yards.
  • Turnovers: 49ers 1, Colts 2.
  • The 49ers' biggest scoring edge came in the 1st quarter (14-7).
  • The 49ers ran for 145 yards to the Colts' 58.

Featured player lines

Player pages exist for the players listed; other players' lines are in StatsNext.

Head-to-head

Earlier meetings stored in StatsNext, most recent first
DateResult
October 24, 2021IND 30, SF 18 (at San Francisco)

About this page

This game is final; the statistics on this page change only if a stored box score is corrected. Team statistics are each team's own box score for this game.

This page shows box-score statistics and results only. It contains no sportsbook prices or betting lines. Current markets, hit rates against the line and StatsNext research are in the app.

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