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Jaguars at 49ers: September 28, 2025

The Jacksonville Jaguars beat the San Francisco 49ers 26-21 at Levi's Stadium on September 28, 2025 (2025 regular season).

Final · Played September 28, 2025 · Updated October 16, 2026 at 10:55 PM ET · StatsNext box-score records

Most passing yards: Trevor Lawrence (Jaguars, 174); Brock Purdy (49ers, 309). Most rushing yards: Travis Etienne Jr. (Jaguars, 124); Christian McCaffrey (49ers, 49). Most receiving yards: Brian Thomas Jr. (Jaguars, 49); Jauan Jennings (49ers, 24).

Scoring by quarter

TeamQ1Q2Q3Q4Final
Jacksonville Jaguars0179026
San Francisco 49ers338721

Team comparison

Team statsJAXSF
Total yards325389
Passing yards174306
Rushing yards15183
First downs1822
Yards per play5.26.2
Turnovers04
Penalty yards9054
Red zone (scores/trips)1/21/3

What stood out

  • The 49ers out-gained the Jaguars 389 to 325 total yards, but the Jaguars won.
  • Turnovers: Jaguars 0, 49ers 4.
  • The Jaguars' biggest scoring edge came in the 2nd quarter (17-3).
  • The Jaguars ran for 151 yards to the 49ers' 83.

Featured player lines

Player pages exist for the players listed; other players' lines are in StatsNext.

Head-to-head

Earlier meetings stored in StatsNext, most recent first
DateResult
November 12, 2023SF 34, JAX 3 (at Jacksonville)
November 21, 2021SF 30, JAX 10 (at Jacksonville)

About this page

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