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Cardinals at 49ers: September 21, 2025

The San Francisco 49ers beat the Arizona Cardinals 16-15 at Levi's Stadium on September 21, 2025 (2025 regular season).

Final · Played September 21, 2025 · Updated October 16, 2026 at 10:55 PM ET · StatsNext box-score records

Most passing yards: Kyler Murray (Cardinals, 159). Most rushing yards: Christian McCaffrey (49ers, 52). Most receiving yards: Marvin Harrison Jr. (Cardinals, 44); Kendrick Bourne (49ers, 38).

Scoring by quarter

TeamQ1Q2Q3Q4Final
Arizona Cardinals033915
San Francisco 49ers0601016

Team comparison

Team statsARISF
Total yards260355
Passing yards154282
Rushing yards10673
First downs1619
Yards per play4.15.7
Turnovers01
Penalty yards3069
Red zone (scores/trips)1/31/4

What stood out

  • The 49ers out-gained the Cardinals 355 to 260 total yards.
  • Turnovers: Cardinals 0, 49ers 1.
  • The 49ers' biggest scoring edge came in the 2nd quarter (6-3).

Featured player lines

Player pages exist for the players listed; other players' lines are in StatsNext.

Head-to-head

Earlier meetings stored in StatsNext, most recent first
DateResult
January 5, 2025SF 24, ARI 47 (at Arizona)
October 6, 2024ARI 24, SF 23 (at San Francisco)
December 17, 2023SF 45, ARI 29 (at Arizona)
October 1, 2023ARI 16, SF 35 (at San Francisco)
January 8, 2023ARI 13, SF 38 (at San Francisco)

Full 49ers vs Cardinals head-to-head (11 meetings).

About this page

This game is final; the statistics on this page change only if a stored box score is corrected. Team statistics are each team's own box score for this game.

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