Cardinals vs 49ers: head-to-head
The Arizona Cardinals and San Francisco 49ers have met 11 times in StatsNext’s stored NFL results, from October 10, 2021 to September 27, 2026 (6 seasons). The 49ers lead 7-4.
Series summary
| Meetings | Games | ARI wins | SF wins | ARI points/g | SF points/g | Total points/g |
|---|---|---|---|---|---|---|
| All meetings | 11 | 4 | 7 | 23.1 | 29.4 | 52.5 |
| At ARI | 4 | 2 | 2 | 28.8 | 30 | 58.8 |
| At SF | 6 | 2 | 4 | 21.5 | 27.5 | 49 |
| Neutral site | 1 | 0 | 1 | 10 | 38 | 48 |
| Last 5 | 5 | 2 | 3 | 27.6 | 28 | 55.6 |
Every stored meeting
| Date | Season | Venue | Score | Winner | Margin | Total |
|---|---|---|---|---|---|---|
| Sep 27, 2026 | 2026 | At SF | ARI 30, SF 36 | SF | 6 | 66 |
| Nov 16, 2025 | 2025 | At ARI | ARI 22, SF 41 | SF | 19 | 63 |
| Sep 21, 2025 | 2025 | At SF | ARI 15, SF 16 | SF | 1 | 31 |
| Jan 5, 2025 | 2024 | At ARI | ARI 47, SF 24 | ARI | 23 | 71 |
| Oct 6, 2024 | 2024 | At SF | ARI 24, SF 23 | ARI | 1 | 47 |
| Dec 17, 2023 | 2023 | At ARI | ARI 29, SF 45 | SF | 16 | 74 |
| Oct 1, 2023 | 2023 | At SF | ARI 16, SF 35 | SF | 19 | 51 |
| Jan 8, 2023 | 2022 | At SF | ARI 13, SF 38 | SF | 25 | 51 |
| Nov 21, 2022 | 2022 | Neutral site | ARI 10, SF 38 | SF | 28 | 48 |
| Nov 7, 2021 | 2021 | At SF | ARI 31, SF 17 | ARI | 14 | 48 |
| Oct 10, 2021 | 2021 | At ARI | ARI 17, SF 10 | ARI | 7 | 27 |
What stands out
- Largest Cardinals win in these meetings: 47-24 on Jan 5, 2025.
- Largest 49ers win: 38-10 on Nov 21, 2022.
- Highest combined score: 74 points (Dec 17, 2023); lowest: 27 (Oct 10, 2021).
- The 49ers have won the last 3 meetings.
- Average margin: 14.5 points per meeting.
How to read this
- These are the final scores of the meetings stored in StatsNext (the 11 most recent, up to 30). Older meetings may not be in these records.
- Rosters, coaches and venues change between seasons, and a few meetings are a small sample: past results describe what happened, not what will happen.
- Scores are final scores.
This page contains no sportsbook prices or betting lines.