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49ers at Cardinals: November 16, 2025

The San Francisco 49ers beat the Arizona Cardinals 41-22 at State Farm Stadium on November 16, 2025 (2025 regular season).

Final · Played November 16, 2025 · Updated October 16, 2026 at 10:55 PM ET · StatsNext box-score records

Most passing yards: Brock Purdy (49ers, 200); Jacoby Brissett (Cardinals, 452). Most rushing yards: Christian McCaffrey (49ers, 81). Most receiving yards: George Kittle (49ers, 67); Michael Wilson (Cardinals, 185).

Scoring by quarter

TeamQ1Q2Q3Q4Final
San Francisco 49ers131210641
Arizona Cardinals7301222

Team comparison

Team statsSFARI
Total yards281488
Passing yards186452
Rushing yards9536
First downs2424
Yards per play5.46.9
Turnovers03
Penalty yards15130
Red zone (scores/trips)4/53/5

What stood out

  • The Cardinals out-gained the 49ers 488 to 281 total yards, but the 49ers won.
  • Turnovers: 49ers 0, Cardinals 3.
  • The 49ers' biggest scoring edge came in the 3rd quarter (10-0).
  • The 49ers ran for 95 yards to the Cardinals' 36.

Featured player lines

Player pages exist for the players listed; other players' lines are in StatsNext.

Head-to-head

Earlier meetings stored in StatsNext, most recent first
DateResult
September 21, 2025ARI 15, SF 16 (at San Francisco)
January 5, 2025SF 24, ARI 47 (at Arizona)
October 6, 2024ARI 24, SF 23 (at San Francisco)
December 17, 2023SF 45, ARI 29 (at Arizona)
October 1, 2023ARI 16, SF 35 (at San Francisco)

Full Cardinals vs 49ers head-to-head (11 meetings).

About this page

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